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Cognitive strategies and reorganisation of cerebral networks in patients with chronic autoimmune encephalitis, before and after hemispherotomy

Rasmussen's encephalitis is a chronic inflammatory disease characterised by progressive atrophy of one cerebral hemisphere associated with drug-resistant partial epilepsy leading to significant neurocognitive disorders. The only curative treatment for this condition is hemispherotomy, which involves functionally disconnecting the affected hemisphere. Despite this major operation, patients operated on in childhood recover almost all their cognitive skills in adulthood, reflecting the gradual implementation of a major cerebral reorganisation. The aim of this project is to evaluate the behavioural (LEXTOMM database developed by our team), cognitive and cerebral performance (i.e. connectomic approach through the evaluation of functional and structural connectivity) of adult patients who underwent hemispherotomy in childhood for Rasmussen's encephalitis. The phenomenon of neuroplasticity is particularly interesting to study in this chronic neurological pathology from both a developmental and a post-injury (i.e. surgery) perspective.

Permanent·es : Monica Baciu, Marcela Perrone-Bertolotti

Doctorant·es : Anna  Borne




Hôpital Fondation Rothschild, Service de Neurochirurgie Pédiatrique; Université de Paris, MC2Lab, Institut de Psychologie, Paris



Submitted on 17 November 2023

Updated on 17 November 2023