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Monica Baciu

Monica Baciu


MD PhD
Professor of Cognitive Neuroscience
IUF senior member
Neurologist


Laboratoire de Psychologie et Neurocognition
CNRS UMR 5105
Université Grenoble Alpes
Bâtiment Michel Dubois
CS40700, 38058 Grenoble Cedex 9
France



firstname.lastname@univ-grenoble-alpes.fr

I am a Professor of Cognitive neurosciences at the University Grenoble Alpes, researcher in the LPNC UMR CNRS 5105 and a neurologist at Grenoble Alpes University Hospital.

Short Vita

I received my MD from the University Iuliu Hatieganu, Cluj Romania in 1990 and did residency in Neurology from 1990 to 1995. I completed my education with a Ph.D. in Cognitive Neuroscience at the University Joseph Fourier (Grenoble Alpes) in 1999. I joined the faculty of the Department of Psychology at the same university in 2000 and I do my research activity in the Laboratoire de Psychologie et Neurocognition (LPNC UMR CNRS 5105) from the Université Grenoble Alpes. I also do clinical activity at Grenoble Alpes University Hospital.

Teaching Activity

Functional neuroanatomy
Neurology and Cognitive Neuropsychology
Functional neuroimaging methods and clinical applications
Neuroplasticity and neurorehabilitation

Research activity

I am interested in studying neurocognitive and integrative models of language and memory, in normal population (aging) and neurological patients (cognitive deficits and neurorehabilitation in epilepsy, Rasmussen encephalitis, stroke and neurodegenerative disorders). I use a multidisciplinary approach that combines cognitive neuroscience, cognitive psychology, neuropsychology, neuroimaging and statistical learning.

Scientific leadership

Current - main

Co-head of the NeuroCoG program : From neuron to networks, from cognition to social interaction https://neurocog.univ-grenoble-alpes.fr/
Co-head of the Cognition program from the Graduate School (SFRI, UGA IDEX)
Coordinator of the project Brain & Cognition Institute
Member of the Biomedical Research and Public Health Committee (CRBSP-fr)
Member of the French National Committee of Scientific Psychology

Previous- main

2012-2020 : Head of the LPNC UMR CNRS 5105 UGA
2009-2012 : Head of the SFR Santé & Société UGA
2008-2012 : Deputy director Doctoral School EDISCE
2008-2012 : Head of the Language & Memory team LPNC
2015-2019 : Member of the Executive Committee Neurodis Foundation

Current supervision

Postdoctoral
Elise ROGER – PhD in Cognitive Neuroscience, 2020-2022

PhD students
Sonja BANJAC – PhD student in Cognitive Neuroscience, 2018-2021
Célise HALDIN - PhD student in Cognitive Neuroscience, 2019-2022
Fabricio DUTRA – neuropsychologist and Cognitive Neuroscience, 2020-2024

Awards and Honors

2019 : Editor’s Choice award : Roger, E., Petit, L., Perrone-Bertolotti, M., Job, A. S., Minotti, L., Kahane, P., & Baciu, M. (2018). The link between structural connectivity and neurocognition illustrated by focal epilepsy. Epileptic Disorders, 20(2), 88-98.

2016 : Prix de la Société Française de Médecine Physique et de Réadaptation (SOFMER) : Baciu, M., Acher, A., Kauffmann, L., Cousin, E., Boilley, C., Hueber, T., Badin, P., Perrier, P., Fabre, D., Jaillard, A., Detante, O., Perennou, D. (2016). Effect of Visual Feedback on speech recovery and language plasticity in patients with post-stroke non-fluent aphasia. Functional MRI assessment. 31st Congress of the French Society of Physical Medicine and Rehabilitation (SOFMER), 13-15 October 2016.

2010-2015 : IUF Senior Member
2015-2020 : IUF Senior Member

2008 : Editors’ Choice award : Jean-Philippe Lachaux, Pierre Fonlupt, Philippe Kahane, Lorella Minotti, Dominique Hoffmann, Olivier Bertrand, Monica Baciu. Relationship between task-related gamma oscillations and BOLD signal : New insights from combined fMRI and intracranial EEG. Human Brain Mapping 28:1368-1375.

2013 : Chevalier Ordre National du Mérite
2016 : Chevalier Légion d’Honneur

Chapters and Books

Gonthier, C., Baciu, M., & Roulin, J.-L. (2018). Approche différentielle et neuroimagerie : l’exemple des différences inter-individuelles en mémoire de travail. In J. Collange, E. Loarer, & T. Lubart (Eds.), La psychologie différentielle au 21ème siècle : nouvelles modélisations et applications (pp. 17-21). Paris, France : Editions Laboratoire LATI. ISBN:978-2-9563911-0-4.

Lœvenbruck, H., Grandchamp, R., Rapin, L., Nalborczyk, L., Dohen, M., Perrier, P., Baciu, M. & Perrone-Bertolotti M. (in press). A cognitive neuroscience view of inner language : to predict and to hear, see, feel. In Inner Speech : nature, functions, and pathology, Peter Langland-Hassan & Agustín Vicente (eds.), Oxford University Press.

Perrone-Bertolotti M., Grandchamp R., Rapin L., Baciu M., Lachaux J.P. & Lœvenbruck H. (2017). Langage intérieur. In Pinto, S. & Sato, M. (eds). Traité de Neurolinguistique. Du cerveau au langage. (pp 109-125) Louvain-La-Neuve : De Boeck.

Perrone-Bertolotti, M., Tzourio-Mazoyer, N., Hoyau, E., Mazoyer, B. & Baciu, M. (2017). Latéralisation hémisphérique du langage : résultats des études comportementales et de la neuroimagerie. In Pinto, S. & Sato, M. (eds). Traité de Neurolinguistique. Du cerveau au langage. (pp147-167) Louvain-La-Neuve : De Boeck.

Perrone-Bertolotti M. & Baciu, M. (2016). Organisation et réorganisation cérébrale du langage:approche pluridisciplinaire. Colloque bisannuel de l’ASL (l’Association de Sciences du Langage) sur le thème Sciences du langage et neurosciences, 21 novembre 2015, pp. 23-44.

Baciu, M. (2012). Plasticité cérébrale du langage et facteurs de réorganisation en "Variations, évolutions, métamorphoses". Les Colloques de l’Institut Universitaire de France (IUF), pp. 67-91.

Baciu, M. (2011). Introduction à la Neuroanatomie Fonctionnelle, De Boeck Université. Louvain la Neuve, Belgique.

Mainy, N., Commiterri, G., Berthoz, A., Baciu, M., Minotti, L., Hoffmann, D., Kahane, P., Bertrand, O., Lachaux, JP. (2009). The timing of neural processes in humans : Beyond the evoked potentials, in Chaos and Complexity : New Research, Elsevier, Pages 279-29.

Baciu, M., Cousin, E. (2008). Functional MRI assessment of language plasticity in epileptic patients. In “Some aspects of speech and the brain”, Ed. Peter Lang Verlag.

Baciu, M., Valdois, S., Kandel, S., Spinelli, E., Cousin, E., Peyrin, C., Lallier, M., Juphard, A., Perrone, M., Soller, O., Alvarez, V., Vallée, N. (2008). Neuropsychology and Cognition of language : Behavioural, neuropsychological and neuroimaging studies of spoken and written language, Ed. Research Signpost.

Juphard, A., Valdois, S., Carbonnel, S., Pichat, C., Ans, B. & Baciu, M. (2008). Length effects in reading : Evidence from behavioural and neuroimaging data. In M. Baciu (Ed.). Neuropsychology and Cognition of Language : Behavioural, Neuropsychological and neuroimaging studies of oral and written language (pp.3-21). Research SignPost.

Savariaux, C., Vilain, C., Baciu, M., Abry, C., Perrier, P., Lebeau, J., Segebarth, C. (2008). Réorganisation du conduit vocal et réorganisation corticale de la parole : de la perturbation aux lèvres à la glossectomie. R. Jouvent & G. Capouthier "Etudes acoustiques et IRMf. La Cognition réparée ? Perturbations et récupérations des fonctions cognitives". Editions de la Maison des sciences de l’homme.

Valdois, S., Peyrin, C & Baciu, M. (2008). The neurobiological correlates of developmental dyslexia. In S. Fuchs, (Eds). Some aspects of speech and the brain. Peter Lang Verlag publisher.

Savariaux, C., Vilain, C., Baciu, M., Abry, C., Perrier, P., Lebeau J., Segebarth, C. (2007). Réorganisation du conduit vocal et réorganisation corticale de la parole : de la perturbation aux lèvres à la glossectomie. Etudes acoustique et IRMf. In C. Fuchs (ed.) "Perturbations et récupérations des fonctions cognitives". Paris, Hermès.

Vilain C., Baciu M., Savariaux C., Lebeau J., Segebarth C., Abry C., Perrier P. (2007). Stratégies de réorganisation cognitive pour la production de parole d’un patient ayant été opéré d’une glossectomie suivie d’une reconstruction linguale : une étude d’IRM fonctionnelle. In Vaxelaire, B., Sock, R., Kleber, G. & Marsac, F. (eds), Perturbations et réajustements, langue et langage. Publication de l’université M. Bloch, Strasbourg 2, pp. 201-209.

Baciu, M. (2006). Explorarea substratului cerebral subiacent limbajului utilizînd tehnica de Imagistica Functionala prin Rezonanta Magnetica Nucleara. Ed. Iuliu Hatieganu, Facultatea de Medicina si Farmacie, Cluj-Napoca, Roumanie.

Baciu, M., Juphard, A., Valdois, S., Carbonnel, S. & Ans, B. (2006). FMRI evidence for ACV98 connectionist model for reading mono- and multi-syllabic words and pseudo-words. In “Brain mapping and language”, New York : NOVA science publishers.

Main publications

Extensive list of publications and communications can be found here :
https://orcid.org/my-orcid
http://www.monica-baciu.com/

2020

Lemaire, C., Dai, S., Piscicelli, C., Clarac, E., Krainik, A., Jaillard, A., Baciu, M. & Pérennou, D. (2020). Functional connectivity of verticality network. Annals of Physical and Rehabilitation Medicine, DOI : 10.1016/j.rehab.2020.101463.

Roger, E., Torlay, L., Gardette, J., Mosca, C., Banjac, S., Minotti, L., Kahane, P. & Baciu, M. (2020). A machine learning approach to explore cognitive signatures in patients with temporo-mesial epilepsy. Neuropsychologia, doi.org/10.1016/j.neuropsychologia.2020.107455.

Roger, E., Pichat, C., Torlay, L., David, O., Renard, F., Banjac, S., Attyé, A., Minotti, L., Lamalle, L., Kahane, P. & Baciu, M. (2020). Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network. Human Brain Mapping, Nov 13. doi : 10.1002/hbm.24839.

Banjac, S., Roger, E., Cousin, E., Perrone-Bertolotti, M., Haldin, C., Pichat, C., Lamalle, L., Minotti, L., Kahane, P., Baciu, M. (2020). Interactive mapping of language and memory with the GE2REC protocol. Brain Imaging and Behavior 2020 Oct 1. doi : 10.1007/s11682-020-00403-6.

Haldin, C., Loevenbruck, H., Hueber, T., Marcon, V., Piscicelli, C., Perrier, P., Chrispin, A., Pérennou, D., Baciu, M. (2020). Speech recovery in post-stroke aphasia with Ultraspeech-player. A case report study. Clinical Linguistics and Phonetics, Jun 22 ;1-24. doi : 10.1080/02699206.2020.1780473.

Perrone–Bertolotti, M., El Bouzaïdi Tiali, S., Vidal, JR., Petton, M., Croize, AC., Deman, P., Rheims, S., Minotti, L., Bhattacharjee, M., Baciu, M., Kahane, P., Lachaux, JP. (2020) Intracranial EEG evidence of a human attentional ‘Gate Keeper’ in the Inferior Frontal Sulcus. Neuroimage, DOI : 10.1016/j.neuroimage.2020.116574.

Cuisenier, P., Testud, B., Minotti, L., El Buzaida Tialli, S., Martineau, L., Job, AS., Trébuchon, A., Deman, P., Bhattacharjee, M., Lachaux, JP., Kahane, P., Baciu, M., Perrone-Bertolotti, M. (2020). Relationship between Direct Cortical Stimulation and induced High Frequency Activity for language mapping during Stereo-EEG recording. Journal of Neurosurgery, Apr 24:1-11. doi : 10.3171/2020.2.JNS192751.

Burnel, M., Durrleman, S., Carré, A., Reboul, A., Baciu, M. & Perrone-Bertolotti, M. (2020). Theory of mind during childhood : Investigating syntactic and executive contributions. Social Development, in press.

Dai, S., Piscicelli, C., Clarac, E., Baciu, M., Hommel, M. & Pérennou, D. (2020). Lateropulsion and gait disorders in subacute stroke. Neurology, 2020 Nov 11 ;10.1212/WNL.0000000000011152, doi : 10.1212/WNL.0000000000011152.

Perrone-Bertolotti, M., Alexandre, S., Job, AS., De Palma, L., Baciu, M., Mairesse, MP., Hoffmann, D., Minotti, L., Kahane, P., David, O. (2020). Probabilistic mapping of language networks from high frequency activity induced by direct electrical stimulation, Human Brain Mapping, epub.

Attyé, A., Renard, F., Baciu, M., Roger, E., Lamalle, L., Dehail, P., Cassoudesalle, H., Calamante, F. (2020). TractLearn : a geodesic learning framework for quantitative analysis of brain bundles. medRxiV, doi : https://doi.org/10.1101/2020.05.27.20113027

2019

Roger, E., Pichat, C., Renard, F., Cousin, E., Perrone-Bertolotti, M., Hot, P., Minotti, L., Job, AS., Kahane, P., Trebuchon, A., Krainik, A. & Baciu, M. (2019). Multimodal assessment of language and memory reorganization : a proof of concept in two patients with drug resistant temporal lobe epilepsy. Epileptic Disorders, 21 (5), 411-424, doi : 10.1684/epd.2019.1092.

Grandchamp, R., Rapin, L., Perrone-Bertolotti, M., Pichat, C., Haldin, C., Cousin, E., Lachaux, JP., Dohen, M., Perrier, P., Garnier, M., Baciu, M. and Loevenbruck, L. (2019). The ConDialInt Model : Condensation, dialogality and intentionality dimensions of inner speech within a hierarchical predictive control framework, Front. Psychol. 10:2019. doi : 10.3389/fpsyg.2019.02019.

Jolly, C., Piscicelli, C., Mathévon, L., Gimat, R., Béranger, C., Guinet, E., Mathevon, L., Chrispin, A., Dai, S., Baciu, M. & Perennou, D. (2019). Tilted writing after stroke, a sign of biased verticality representation, Jan ;63(1):85-88. doi : 10.1016/j.rehab.2019.12.001.

Haldin, C., Acher, A., Kauffmann, L., Hueber, T., Cousin, E., Badin, P., Perrier, P., Fabre, D., Perennou, D., Detante, O., Jaillard, A., Loevenbruck, H. & Baciu, M. (2019). Effet de la rééducation perceptivo-motrice sur la récupération de la parole chez deux patientes avec aphasie non fluents chroniques post-AVC. Revue de Neuropsychologie, 11(1):44-59, DOI : 10.1684/nrp.2019.0485.

2018

Kuzovkin, I., Vicente, R., Petton, M., Lachaux, JP., Baciu, M., Kahane, P., Rheims, S., Vidal, JR., Aru, J. (2018). Activations of Deep Convolutional Neural Network are Aligned with Gamma Band Activity of Human Visual Cortex. Nature Communications Biology 1 : 107 (2018). doi : 10.1038/s42003-018-0110-y.

Hoyau, E., Roux-Sibilon, A., Boudiaf, N., Pichat, C., Cousin, E., Krainik, A., Jaillard, A., Peyrin, C. & Baciu, M. (2018). Aging modulates fronto-temporal cortical interactions during lexical production. A dynamic causal modeling study. Brain Language, Jun 15 ;184:11-19. doi : 10.1016/j.bandl.2018.06.003.

Roger, E., Petit, L., Perrone-Bertolotti, M., Job, AS., Minotti, L., Kahane, P. & Baciu, M. (2018). Structural connectivity and neurocognition : contribution to focal epilepsy. Epileptic Disorders doi : 10.1684/epd.2018.0958.
Burnel, M., Perrone-Bertolotti M., Reboul, A., Baciu, M. & Durrleman, S. (2018). Reducing the language content in ToM tests : a developmental scale, Developmental Psychology. Nov 20. doi : 10.1037/dev0000429.

Hoyau, E., Gigleux, M., Cousin, E., Fournet, N., Pichat, C., Jaillard, A. & Baciu, M. (2018). Effet des facteurs environnementaux sur la production lexicale lors du vieillissement normal. Approche multimodale. Geriatr Psychol Neuropsychiatr Vieil. doi : 10.1684/pnv.2017.0715.

Ramanoel, S., Hoyau, E., Kauffmann, L., Renard, F. Pichat, C., Boudiaf, N., Krainik, A., Jaillard, A. & Baciu, M. (2018). The effect of normal aging and cognitive performance on cerebral gray matter atrophy. A Voxel-Based Morphometry study. Frontiers in Aging Neuroscience, DOI : 10.3389/fnagi.2018.00235.

Gornushkina, I., Jaillard, A., Pichat, C., Piscicelli, C., Baciu, M., Perennou, D. (2018). Evaluating functional connectivity of verticality perception network in healthy participants and stroke patients. Annals of Physical and Rehabilitation Medicine, Vol. 61, page e414, https://doi.org/10.1016/j.rehab.2018.05.964.

2017

Haldin, C., Acher, A., Kauffmann, L., Hueber, T., Cousin, E., Badin, P., Perrier, P., Fabre, D., Perennou, D., Detante, O., Jaillard, A., Lœvenbruck, H. & Baciu, M. (2017). Speech recovery and language plasticity can be facilitated by Sensori-Motor Fusion training in chronic non-fluent aphasia. A case report study. Clin Linguist Phon. 2017 Nov 17:1-27. doi : 10.1080/02699206.2017.1402090.

Torlay, L., Perrone-Bertolotti, M., Thomas, E., Baciu, M. (2017). Machine Learning XGBoost Analysis of language networks to classify patients with epilepsy. Brain Informatics. doi.10.10007/s40708-017-0065-7.

Prevost, M., Hot, P., Muller, L., Ruffieux, B., Crosetto, P., Pichat, C., Cousin, E. & Baciu, M. (2017). Neural correlates of the healthiness evaluation processes of food labels. Nutritional Neuroscience. doi.org/10.1080/1028415X.2017.1309820.

Hoyau, E., Boudiaf, N., Cousin., E., Pichat, C., Fournet, N., Krainik, A., Jaillard, A. & Baciu, M. (2017). Aging Modulates the Hemispheric Specialization during Word Production. Frontiers in Aging Neuroscience. doi. 10.3389/fnagi.2017.2017.00125.

Perrone-Bertolotti M., Kauffmann L., Pichat C., Vidal J.R. & Baciu M. (2017). Ventral and dorsal stream modulation by phonological and semantic processing during visual word recognition. A dynamic causal modeling study. Frontiers Human Neuroscience, 11, doi : 10.3389/fnhum.2017.00325.

Burnel, M., Perrone-Bertolotti, M., Durrleman, S., Reboul, A., Baciu, M. (2017). Role of two embedded syntaxes for belief attribution in adults with or without Asperger syndrome. Frontiers in Psychology-Language Sciences. Research Topic "Investigating Grammar in Autism Spectrum Disorders".

2016

Boudiaf, N., Laboissière, R., Cousin, E., Fournet, N., Krainik, A. & Baciu, M. (2016). Behavioral evidence for a differential modulation of semantic processing and lexical production by aging. A full linear mixed-effects modeling approach. Aging, Neuropsychology and Cognition, Nov 24:1-22, DOI : 10.1080/13825585.2016.1257100.

Tzourio-Mazoyer N., Perrone-Bertolotti M., Jobard G., Mazoyer B., Baciu M. (2016). Multi-factorial modulation of language variability and plasticity in healthy and pathological condition : a review. Cortex, pii : S0010-9452(16)30130-7. doi : 10.1016/j.cortex.2016.05.013.

Baciu, M., Acher, A., Kauffmann, L., Cousin, E., Boilley, C., Hueber, T., Badin, P., Perrier, P., Fabre, D., Jaillard, A., Detante, O., Perennou D. (2016). Effect of visual feedback on speech recovery and language plasticity in patients with post-stroke non-fluent aphasia. Functional MRI assessment. Ann Phys Rehabil Med. 2016 Sep ;59S:e75-e76. doi : 10.1016/j.rehab.2016.07.176.

Acher, A., Fabre, D., Hueber, T., Badin, P., Detante, O., Cousin, E., Pichat, C., Jaillard, A. & Baciu, M. (2016). Retour visuel en aphasiologie : résultats comportementaux, acoustiques et en neuroimagerie. Actes XVIèmes Rencontres Internationales d’Orthophonie, Paris, 2016, pp 1-33.

Baciu, M., Boudiaf, N., Cousin, E., Perrone-Bertolotti, M., Pichat, C., Fournet, N., Chainay, H., Lamalle & Krainik, A. (2016). Functional MRI evidence for the decline of word retrieval and generation during normal aging. Age, Journal of the American Aging Association, Feb ;38(1):3.doi : 10.1007/s11357-015-9857-y. Epub 2015.

Campagne, A., Fradcourt, B., Pichat, C., Baciu, M. & Peyrin, C. (2016). Cerebral correlates of emotional and motivational appraisals during visual processing of emotional scenes depending on spatial frequency. PlosOne, 2 ;11(1):e0144393. doi:10.1371/journal.pone.0144393.

Perrone-Bertolotti, M., Cerles, M., Ramdeen, K., Boudiaf N., Pichat C., Hot, P., Baciu, M. (2016). The self-pleasantness judgment modulates the encoding performance and the Default Mode Network activity. Frontiers in Human Neuroscience, 10:1-12 ; 10.3389/fnhum.2016.00121.

2015

Hoyau, E., Cousin, E. Jaillard, A. & Baciu, M. (2015). Modulation of inter-hemispheric processing of semantic information during normal aging : a divided visual field experiment. Neuropsychologia doi:10.1016/j.neuropsychologia.2015 Epub.

Favre, P., Houennou, J., Baciu, M., Pichat, C., Poupon, C., Bugerol, T., Polosan, M. (2015). White matter plasticity induced by psychoeducation in bipolar patients : A controlled diffusion tensor imaging study. Psychotherapy and Psychosomatics, 27 ;85(1):58-60.
Perrone-Bertolotti, M., Girard, C., Cousin, E., Vidal, J.R., Pichat, C., Kahane, P., & Baciu, M. (2015). NEREC, an effective brain mapping protocol for combined language and long-term memory functions. Epilepsy & Behavior, 53, 140-148.

Favre, P., Polosan, M., Pichat, C., Bugerol, T., Baciu, M. (2015). Cerebral Correlates of Emotional Conflict Processing in Euthymic Bipolar Patients : A functional Connectivity Study. PlosOne, 10(8):e0134961.doi:10.1371/journal.pone.0124961.

Baciu, M. & Perrone-Bertolotti, M. (2015). What do patients with epilepsy tell us about language dynamics ? A reviews of fMRI studies. Reviews in the Neurosciences. 26(1). 1-19.