Twice-daily neuronavigated intermittent theta burst stimulation for bipolar depression: A Randomized Sham-Controlled Pilot Study.
The safety and efficacy of neuronavigated intermittent theta burst stimulation (iTBS) in patients with bipolar depression has not yet been investigated. We hypothesized the superiority of active iTBS over sham. Twenty-six patients were randomly allocated to receive either active (n=12) or sham (n=14) iTBS. Response and remission rates according to changes in depression MADRS score were high following active iTBS (72% and 42% for response and remission rates, respectively), but no significant difference was found after sham stimulation (42%and 25%). No adverse events were observed. This study revealed the safety and tolerability of twice daily iTBS in patients with bipolar depression. Larger controlled studies are warranted to prove iTBS superiority in treatment-resistant bipolar depression.
Références
- Titre
- Twice-daily neuronavigated intermittent theta burst stimulation for bipolar depression: A Randomized Sham-Controlled Pilot Study.
- Type de publication
- Article de revue
- Année de publication
- 2019
- Auteurs
- Bulteau S, Beynel L, Marendaz C, Dall'Igna G, Peré M, Harquel S, Chauvin A, Guyader N, Sauvaget A, Vanelle J-M, Polosan M, Bougerol T, Brunelin J, Szekely D
- Revue
- Neurophysiologie clinique = Clinical neurophysiology
- Volume
- 49
- Pagination
- 371–375
- ISSN
- 1769-7131
- Mots-clés
- Adult, Bipolar depression, Bipolar Disorder, Depressive Disorder, Dorsolateral prefrontal cortex, Female, Humans, Major, Male, methods, Neuronavigation, physiology, physiopathology, Pilot Projects, Prefrontal Cortex, Randomized pilot trial, Repetitive transcranial magnetic stimulation, Resistant depression, Theta burst stimulation, Transcranial Magnetic Stimulation, Treatment Outcome, Treatment-Resistant, Young Adult
Soumis le 9 juin 2022