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Jeremy Gadette

Jérémy Gardette

Vision & Emotion Team
PhD : Hippocampus-dependant cognitive deficits in early Alzheimer’s Disease

Research overview

Alzheimer’s disease is a neuroprogressive pathology leading to brain atrophies, initially concerning medial temporal structures such as the Hippocampus. The hippocampus is typically associated with memory, and its dysfunction is believed to cause memory deficits. However, recent neuropsychological models propose that the hippocampus and surrounding cortices are not specialised in one cognitive function, but rather in a kind of representation to process. Therefore, these structures should be involved in various cognitive processes (i.e., memory, perception, working memory) that imply to manipulate these representations. The first step of our research is to investigate the predictions of these different models via neuroimaging techniques (e.g., fMRI). In a second step, we aim to apply our results to Alzheimer’s disease patients, in order to improve our understanding of the cognitive deficits found in this population.

The main models we are studying are the Scene Construction Theory (developed by Maguire and colleagues in London), the Hierarchical-Representational Model (developed by Bussey & Saksida in Cambridge and Barense in Toronto), and the High-Resolution Binding theory (developed by Yonelinas in Davis, California).

1st year : Experimental methodology (USMB)
2nd year : Psychometry (USMB)
2nd year : Questionnaire building (USMB)