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Brice Passera

Brice Passera


1251 av Centrale
Domaine universitaire
38052 Grenoble cedex 9

OHBM 2019
Modulation of visual hallucinations induced by occipital cortex deafferentation using robotized transcranial magnetic stimulation : a case study


Advisors :

  • Olivier DAVID, PhD, DR INSERM, Grenoble Institut des Neurosciences (GIN)
  • Alan CHAUVIN, PhD, MCF UGA, Laboratoire de Psychologie et NeuroCognition (LPNC)
  • Sylvain HARQUEL, PhD, IR CNRS, Laboratoire de Psychologie et NeuroCognition (LPNC)

Thesis :

Imaging of cortical excitability with transcranial magnetic stimulation and electroencephalography in de novo Parkinsonian patients

Parkinson’s disease (PD) is the second most frequent neurodegenerative disorder. Unfortunately, there is no cure for PD and no neuroprotective treatment and about 95% of patients will become demented within 25 years after the diagnosis. The presentation and evolution of PD is highly heterogeneous between patients : different subtypes of the disease have been described, based on motor signs (for example, tremor-dominant or rigid-bradykinetic types) (Selikhova et al., 2009) and, more recently, on non-motor signs (cognitive or neocortical, autonomic and limbic subtypes) (Marras and Chaudhuri, 2016). Some PD phenotypes, namely the bradykinetic-rigid and neocortical forms, are more at risk of having a more severe and progressive course of the disease. However, although cognitive deficits are very frequent in old patients (Aarsland et al., 2007), in younger patients it is difficult to predict whether they will develop early cognitive disturbances, despite the availability of some biomarkers that are linked to higher risk of dementia (Svenningsson et al., 2012). Hence, subtyping PD patients at an early disease stage to predict the evolution to dementia is a useful strategy for personalizing patients’ management, and for guiding research on new medical approaches, including early use of neuroprotective therapies (Moro et al., 2016). In this proposal, we assume that in patients with a PD subtype characterized by prevalent cognitive issues, the impairment of cortical excitability in the fronto-parietal networks (Gratwicke et al., 2015) would be a new biomarker already detectable at an early disease stage. We will study the cortical excitability using innovative methodologies for brain stimulation that we recently developed. These are based on the concepts of functional cytoarchitectony (Harquel et al., 2016) and functional tractography (David et al., 2013), probing local and large scale neuronal communication with cortical stimulation, respectively.

Publications :

  • Harquel, S., Diard, J., Raffin, E., Passera, B., Dall’Igna, G., Marendaz, C., David, O., Chauvin, A. (2017). Automatized set-up procedure for transcranial magnetic stimulation protocols. Neuroimage.

Communications :

  • Passera, B., Harquel, S., Vercueil, L., David, O., Chauvin, A., 2019. Modulation of visual hallucinations induced by occipital cortex deafferentation using robotized transcranial magnetic stimulation : a case study. OHBM Meeting 2019.
  • Raffin, E., Harquel, S., Passera, B., Siebner, H., David, O., 2019. Different input-output properties throughout the cortex as revealed by TMS-EEG. Brain Stimul. Basic Transl. Clin. Res. Neuromodulation 12, 511–512.
  • B. Passera, E. Raffin, S. Harquel, H.R. Siebner, O. David. Distinct input-output dynamics throughout the cortex highlight region-specific cortical excitability properties. 6th FENS Science Factory : TMS–EEG Summer School and Workshop, 2018 May 17-24th, Espoo, Finland
  • E. Raffin, S. Harquel, P. Favre, L. Beynel, B. Passera, O, David, M. Polosan. Linking dysfunctional premotor-to.motor connectivity to disease severity of Obsessive-compulsive disorder : a robotic dual-site TMS study. 10th FENS, 2016 July 2-7th, Copenhagen, Danemark

Education :

Master 2, Research, Cognitives Sciences - PHELMA – Institut National Polytechnique GRENOBLE - 2017

Master Thesis : Modulation of Visuo-Attentional Network using rTMS

  • dir. Estelle RAFFIN, Sylvain HARQUEL and Olivier DAVID

Master 1, Cogntive and social Psychologie - Université Grenoble Alpes - 2016

Master Thesis : Automatization of TMS parametrization protocols

  • dir. Alan CHAUVIN and Sylvain HARQUEL

B.A. in Psychology - Université Grenoble Alpes - 2015